GPAT Practice Test Online
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GPAT Practice Test Online
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Question 1 |
Quinoline alkaloids are biosynthesized via which one of the following pathways?
Shikimic acid - tyrosine | |
Shikimic acid - tryptophan | |
Shikimic acid -
cathinone
| |
Shikimic acid - phenylalanine |
Question 2 |
Khellin is an active constituent of which one of the following plants?
Prunus serona | |
Tribulus terrestis | |
Ammi visnaga | |
Vanilla planifolia |
Question 3 |
Which one of the following compounds is useful for the stimulation of cell division
and release of lateral bud dormancy?
Zeatin | |
2,4-Dichlorophenoxyacetic acid | |
Indoleacetic acid | |
Picloram |
Question 4 |
A powdered drug has the following microscopic characters:
Anther cells, arenchyma, pollen grains, phloem fibers, volatile oil cells and stone cells. The powder is obtained from which of the followings?
Clove bud powder | |
Clove bud powder with stalk | |
Mother Clove | |
None of the above |
Question 5 |
Which of the following ergot alkaloids is water soluble and shows blue fluorescence?
Ergosine | |
Ergotamine | |
) Ergocristine | |
) Ergometrine |
Question 6 |
Goldbeater's skin test is used to detect the presence of which one of the following classes of compounds?
Tannins | |
Steroids | |
Glycerides | |
Resins |
Question 7 |
Phenylethylisoquinoline is the precursor of which of the following alkaloids?
Colchicine | |
Papaverine | |
Emetine | |
Cephaline |
Question 8 |
Arrange the following fatty acids in decreasing order of their unsaturation (highest to lowest):
[P] Stearic [Q] Oleic acid [R] Linolenic acid [S] Linoleic acid
P>Q>R>S | |
S>R>P>Q | |
R>S>Q>P | |
Q>P>R>S |
Question 9 |
Each Of the following options lists a phytoconstituent, its phytochemical grouping, pharmacological activity and corresponding semisynthetic analogue. Find a MISMATCHING option.
Podophyllotoxin, lignan, anticancer, etoposide | |
Sennoside, anthraquinone, laxative, sinigrin | |
Atropine, alkaloid, anticholinergic, homatropine | |
THC. terpenophenolic, psychoactive, nabilone |
Question 10 |
Which of the following mechanisms is NOT related to platelet aggregation inhibitory action?
ADP receptor antagonism | |
Glycoprotein IIb/IIIa receptor antagonism | |
Phosphodiesterase inhibition | |
Prostacvclin inhibition |
Question 11 |
Which of the following species is being inactivated by the enzyme Dipeptidyl
peptidase-4?
Oxytocin | |
Vasopressin | |
Incretin | |
Glucagon |
Question 12 |
Two genetic types of Cannabis i.e. drug type and Hemp type are cultivated.
[P] Drug type cannabis is rich in (-)A-trans-tetrahydrocannabinol .
[Q] Hemp type cannabis is rich in cannabidiol
[R] Drug type cannabis is rich in cannabidiol -
[S] Hemp type cannabis contains elongated bast fibres
Which one of the given statements is correct?
P is true, Q is true, R is true, S is true | |
P is true, Q is false, R is false, S is true | |
P is true, Q is true, R is false, S is true | |
P is false, Q is false, R is true, S is false |
Question 13 |
Inhibition/induction of which of the following Cytochrome P450enzyme system is most likely to be involved in important drug-druginteractions?
CYP3A4 | |
CYP2D6 | |
CYP2C9 | |
CYP1A2 |
Question 14 |
Choose the correct statement about the given four diseases?
[P] Cardiomyopathy ],Q] Rheumatoid arthritis
[R] Myasthenia gravis [S] Ulcerative colitis
Q & S are autoimmune disorders | |
P & Q are autoimmune disorders | |
P & R are not autoimmune disorders | |
R & S are not autoimmune disorders |
Question 15 |
Most of the emergency contraceptives have one of the following active ingredients?
Estradiol | |
Norethindron | |
Misoprostol | |
Levonorgesterel |
Question 16 |
Antiretroviral Raltegravir is unique, because of which of its following actions?
Integrase inhibition | |
CCR5 Co-receptor antagonism | |
Fusion inhibition | |
Reverse transcriptase inhibition |
Question 17 |
Which one of the followings is NOT an example of G-protein coupled receptor?
Muscarinic cholinergic receptor | |
Alpha adrenoceptor | |
Nicotinic cholinergic
receptor
| |
Beta adrenoceptor |
Question 18 |
Which of the following statements is FALSE for artemisinin?
It is a sesquiterpene lactone endoperoxide | |
It is a drug of choice in prophylaxis of malaria | |
It does not cure relapsing malaria | |
It is useful in treatment of cerebral falciparum malaria |
Question 19 |
Which of the following antibiotics produces concentration dependent bactericidal action and also possesses post-antibiotic effect?
Ceftazidime | |
Azithromycin | |
Amikacin | |
Piperacillin |
Question 20 |
What is chemotaxis?
Toxicity of chemicals | |
Taxonomy of chemicals | |
Inhibition of Inflammation | |
Movement of leucocytes in inflammation |
Question 21 |
Which of the followings used in the treatment of rheumatoid arthritis is NOT a biologic response modifier?
Anakinra | |
Leflunomide | |
Etanercept | |
Infliximab |
Question 22 |
Which of the followings is a noncompetitive inhibitor of the enzyme reverse
transcriptase in HIV?
Lamivudine | |
Nevirapine | |
Abacavir | |
Tenofovir |
Question 23 |
Which one of the followings is a beta lactamase inhibitor?
Penicillanic acid | |
Embonic acid | |
Cephalosporanic acid | |
Clavulanic acid |
Question 24 |
Neural tube defects may occur by which one of the following anti-seizure drugs?
Ethosuximide | |
Vigabatrin | |
Valproic acid | |
Primidone |
Question 25 |
Which one of the following drying methods is commonly used in pharma industry for drjing of soft shell capsules?
Truck drying | |
Fluid bed drying | |
Vacuum drying | |
Microwave drying |
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GPAT Question Answers Mock Test
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Question 1 |
If C is the concentration of dissolved drug and Cs is the saturation concentration. In which case the sink conditions are said to be maintained?
C < 20% of Cs | |
C > 20% of Cs | |
C < 10% of Cs | |
C >10% of Cs |
Question 2 |
All of the followings are indications for use of ACE inhibitors EXCEPT for one. Identify that.
Hypertension | |
Myocardial infarction | |
Left ventricular dysfunction | |
Pheochromocytoma |
Question 3 |
Which water is used for hand washing in a change room of pharmaceutical manufacturing plant?
Potable water | |
Purified water | |
Disinfectant water | |
Soap water |
Question 4 |
Which one of the followings does NOT afford a macromolecular inclusion
compound?
Zeolites | |
Dextrins | |
Silica gels | |
Cyclodextrins |
Question 5 |
Which condition does not apply as per Indian law while conducting single dose bioavailability study of an immediate release product?
Sampling period should be atleast three t1/2 ei | |
Sampling should represent pre-exposure, peak exposure and post-exposure phases | |
There should be atleast four sampling points during elimination phase | |
Sampling should be continued till measured AUC is atleast equal to 80% of AUC |
Question 6 |
Which of the following isothem are produced when the heat of condensation of successive layers is more than the heat of adsorption of first layer?
Type III and IV | |
Type II and V | |
Type I and III | |
Type III and V |
Question 7 |
The minimal effective flow rate of air in Luminar Flow hood should be not less than how many cubic feet per minute?
10 | |
50 | |
100 | |
1000 |
Question 8 |
Which of the following pumps is used in handling of corrosive liquids?
Turbine pump | |
Volute Pump | |
Air binding pump | |
Baltic pump |
Question 9 |
Convert 90% v/v alcohol to Proof strength. Choose the correct answer.
57.77° under proof | |
57.77° over proof | |
47.41° over proof | |
47.41° under proof |
Question 10 |
What is the Heat of vaporization of water at 100:
2790 cal/ mole | |
7290 cal / mole | |
7920 cal/mole | |
9720 cal/mole |
Question 11 |
Which of the followings act as a non-ionic emulsifying agent?
Triethanolamine oleate | |
Polyoxyethylene sorbitan monooleate | |
N-Cetyl-N-ethylmorpholinium ethosulfate | |
Dioctyl sulphosuccinate |
Question 12 |
Which of the following Schedules include shelf life of drugs?
Schedule F | |
Schedule M | |
Schedule G | |
Schedule P |
Question 13 |
By addition of which of the followings the shells of soft gelatin capsules may be made elastic?
Polyethylene glycol | |
Sorbitol | |
Propylene glycol | |
Dibutyl phthalate |
Question 14 |
Department of Transport Test (DOT) is performed for which of the followings?
Strip packing | |
Aerosols | |
Injection packing | |
Glass containers |
Question 15 |
How many mL of 50% (w/v) dextrose solution and how many mL of 5% (w/v)
dextrose solution are required to prepare 4500 mL of a 10% (w/v) solution?
500 mL of 50% and 4000 mL of 5% | |
1000 mL of 50% and 3500 mL of 5% | |
4000 mL of 50% and 500 mL of 5% | |
1500 mL of 50% and 3000 mL of 5% |
Question 16 |
P-Glycoprotein pump is responsible for which one of the followings?
Transporting the drugs from the enterocytes into the gut lumen | |
Transporting the drugs from gut lumen into enterocytes | |
Transporting the drugs from oral mucosa into blood capillaries | |
Transporting the drugs from Peyer's patches into the gut lumen. |
Question 17 |
The first stage of wetting on addition of a granulating agent to the powders is characterized by which one of the followings?
Capillary state | |
Pendular state | |
Funicular state | |
Droplet state |
Question 18 |
The degree of flocculation of a suspension is 1.5 and the sedimentation volume is 0.75. What will be the ultimate volume of deflocculated suspension?
2.0 | |
1.5 | |
0.75 | |
0.5 |
Question 19 |
A drug is administered to a 65 Kg patient as 500 mg tablets every 4 hours. Half- life of the drug is 3 h, volume of distribution is 2 liter/Kg and oral bioavailability of the drug is 0.85. Calculate the steady state concentration of the drug?
5.05mcg/ml | |
4.50 mcg/ml | |
3.53 mcg/ml | |
3.00 mcg/ml |
Question 20 |
Statement [X] : Hofmeister series grades coagulating power of electrolytes as per their ionic size. Statement [Y] : The relative coagulating power is given by:[P] Al+++ > Ba++ [Q] Li- > F- [R] NH4+ > Na+ Choose the correct statement :
Statement X is true but P, Q and R are false in Statement Y | |
Statement X is false and P, Q and R are false in Statement Y | |
Statement X is true and Q and R are false in Statement Y | |
Statement X is false and P is false in Statement Y |
Question 21 |
Larger values of Ky in the Heckel Plot indicate formation of what quality of tablets?
Harder tablets | |
Softer tablets | |
Fluffy tablets | |
Brittle tablets |
Question 22 |
Which is NOT applicable to protein binding?
Klotz reciprocal plot | |
Sandberg modified equation | |
Blanchard equation | |
Detli plot |
Question 23 |
According to USP, the speed regulating device of the dissolution apparatus should be capable of maintaining the speed within limits of what % of the selected speed?
1% | |
2% | |
4% | |
5% |
Question 24 |
Which statement is NOT true for steam distillation?
It is also called differential distillation | |
It can be used for separation of immiscible liquids - | |
It can be applied for volatile substances | |
It can be used for separation of miscible liquids |
Question 25 |
What is Primogel?
Substituted HPMC for direct compression | |
Modified microcrystalline cellulose for direct compression | |
Hydro gelling polymer for gel formation | |
Modified starch for disintegration |
Once you are finished, click the button below. Any items you have not completed will be marked incorrect.
There are 25 questions to complete.
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