Pathology Quiz Question & Answers

Pathology Quiz Question & Answers (Question Bank) Free Online Test For Medical Students like PG, PHD, Specialist exam entrance.

Pathology Means:  “the science of the causes and effects of diseases, especially the branch of medicine that deals with the laboratory examination of samples of body tissue for diagnostic or forensic purposes”.

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Pathology Quiz Question & Answers (Total 50 MCQs)

Pathology Online Mock Test (High level)

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Question 1
Insulin resistance in diabetes results in all of the following except:
A
failure to inhibit endogenous glucose production
B
failure to glucose uptake and glycogen synthesis in skeletal muscles following a meal
C
failure to inhibit post-prandial lipase in adipose tissue
D
failure to neoglucogenesis
Question 2
Which of the following statements regarding macrophage activation pathway is false?
A
Alternatively activated macrophage (M2) causes injury of adjacent normal tissue.
B
M2 macrophages are not actively microbicidal
C
Classically activated macrophages (M1) produce NO and ROS
D
Classical activation of macrophage is induced by endotoxin
Question 3
Micro-RNA (miRNA)
A
encodes protein synthesis
B
inhibits function of mRNA
C
is associated with posttranscriptional silencing of gene expression
D
is not a conserved mechanism of gene regulation
Question 4
Which of the following type is a non-fibrillar collagen?
A
Type II
B
Type III
C
Type IV
D
Type V
Question 5
Which of the following lesion is associates with osteoid deposition?
A
chondosarcoma
B
osteosarcoma
C
giant cell tumor of bone
D
Ewing sarcoma
Question 6
Which of the following is a source of histamine during inflammation?
A
platelet
B
neutrophil
C
hepatocyte
D
lymphocyte
Question 7
Which one of the following serological test is not positive in cases of Primary biliary cirrhosis?
A
AMA
B
ANA
C
ANCA
D
dsDNA
Question 8
Which is the best method to localise fibrin on glomerular basement membrane
A
Periodic acid-schiff stain
B
Trichrome Stain
C
Silver methenamine stain
D
Phosphotungstic acid haematoxylin stain
Question 9
Spinocerebellar degeneration is caused by deficiency of  
A
Vitamin A
B
Vitamin B1
C
Vitamin E
D
Niacin
Question 10
The Genome Wide Association Studies (GWAS) are done in
A
small cohort of families with a particular disease
B
large cohort of families with a disease
C
large cohort with or without disease rather than families
D
large cohort of families without disease in specific geographic area or population
Question 11
All of the following factors are associated with development o urinary bladder carcinoma except:
A
cigarette smoking
B
exposure to aryl amine
C
Schistosomahaematobium
D
Exposure to arsenic
Question 12
Which of following protein is pro-apoptotic?
A
BAK
B
MCL1
C
BCL-XL
D
BCL2
Question 13
Which of the following virus is associated with cervical carcinoma?
A
Herpes Simplex Virus
B
HPV
C
HIV
D
HTLV
Question 14
Which of the following is not a bullous disease of the skin?
A
Lichen planus
B
Pemphigus vulgaris
C
Bullous pemphigoid
D
Dermatitis herpetiformis
Question 15
The most sensitive test for diagnosis of Celiac disease is
A
C reactive protein
B
Serum IgE
C
IgA antibody against tissue transglutaminase
D
Anti mitochondrial antibody
Question 16
Multiplex Ligation-Dependent Probe Amplification (MPLA)
A
is a technique similar to fluorescence in-situ hybridization
B
is a part of cytogenomic array technology
C
is same as Array-Based comparative Genomic Hybridization (Array CGH)
D
is a technique which combines DNA hybridization, DNA ligation and PCR amplification to detect deletions and duplications of any size
Question 17
Which one of the following protein is NOT involved in formation intercellular tight junction?
A
claudin
B
laminin
C
catenin
D
zonulin
Question 18
Which one of the following is not associated with oxidation of alcohol in liver?
A
dehydrogenase
B
cytochrome P-450 system
C
catalase
D
peroxidase
Question 19
The gene involved in pathogenesis of Familial adenomatous polyposis is
A
c-abl
B
n-myc
C
APC
D
MYH
Question 20
All of the following are risk factor for peptic ulcer disease except:
A
H pylori infection
B
Cigarette smoking
C
Chronic obstructive pulmonary disese
D
Diabetes
Question 21
Prenatal testing should be offered for all pregnancy for fetal cytogenetic abnormality in all of the following situations except:
A
advanced maternal age
B
a parent known to carry a balanced chromosomal rearrangement
C
maternal diabetes
D
fetal anomalies observed on ultrasound examination
Question 22
All of the following hepatic lesions can be produced by Hepatitis B virus except:
A
non-progressive chronic hepatitis
B
progressive chronic disease and cirrhosis
C
acute hepatic failure with massive hepatocellular necrosis
D
intrahepatic micro-abscess
Question 23
Gastrointestinal Stromal Tumor (GIST) is associated with mutation of
A
k-RAS
B
c-myc
C
p53
D
receptor tyrosin kinase KIT
Question 24
Typhoid ulcer
A
is concentric and transverse ulcer
B
it occurs in large intestine
C
is associated wit gastritis
D
involve Peyer patches in small intestine
Question 25
Which one of the following is ANCA associated vasculitis?
A
Kawasaki disease
B
Takayasu arteritis
C
Goodpasture disease
D
Chrug-Strauss Syndrome
Question 26
An example of trinucleotide-repeat mutation associated genetic disorder is
A
cystic fibrosis
B
fragile X syndrome
C
Wilson disease
D
Phenylketonuria
Question 27
Polycystic ovarian syndrome is not characterized by:
A
hypoandrogenism
B
menstrual abnormality
C
chronic anovulation
D
decreased fertility
Question 28
Linear pattern of localization of immunoglobulins on the glomerular basement membrane by immunofluorescence is seen
A
Membranoproliferative GN
B
Membranous GN
C
Minimal change GN
D
Anti-GBM nephritis
Question 29
All of the following are associated with generation of free radicles EXCEPT
A
The reduction-oxidation reaction during metabolic process
B
Fenton reaction
C
Absorption of radiation
D
Interaction with Glutathione Peroxidase
Question 30
Metaplasia is
A
an irreversible change
B
associated with replacement of one undifferentiated cell type with another differentiated cell
C
a variant of dysplasia
D
associated with vitamin A deficiency which may involve respiratory epithelium
Question 31
Pathogenesis of septic shock may be associated with recognition of microbe derived substance by all of the following except
A
Pathogen associated molecular patterns (PAMPs)
B
G protein coupled receptor
C
Aquaporin 1
D
Nucleotide oligomerisation domain protein 1 (NOD1)
Question 32
The principal site of vitamin 1,25(OH)2D3 production is 
A
Bone
B
Kidney
C
Liver
D
Skin following exposure to sunlight
Question 33
Which of the following mediators suppresses inflammation?
A
Prostaglandin
B
Prostacyclin
C
Lipoxin
D
Leukotriene
Question 34
Wilson Disease is
A
an autosomal dominant disease
B
associated with mutation of wt1 gene
C
caused by mutation of ATP7B gene
D
associate with defect in iron metabolism
Question 35
BRCA1 familial breast cancer is associated with
A
ER and PR positive cancer cells
B
Poorly differentiated cancer which are triple negative
C
HER2Nu positive and ER, PR negative
D
ER positive and PR negative cancer cell
Question 36
Which of the following disease is associated with loss of podocyte?
A
minimal change disease
B
mesangioproliferative glomerulonephritis
C
focal segmental glomerulosclerosis
D
membranoproliferative glomerulonephritis
Question 37
All of the following are associated with H pylori associated gastritis except:
A
it involves antral region
B
Gastrin secretion is increased
C
Predisposes to develop peptic ulcer
D
Associated with adenocarcinoma
Question 38
All of the following are favorable prognostic feature of Neuroblastomaexcept:
A
Age bellow 18 month
B
Presence of schwannianstroma and gangiocytic differentiation in histology
C
Near diploid nuclei
D
Absence of chromosome 1p loss
Question 39
Which of the statement for bradykinin is true in relation to inflammation?
A
It decreases vascular permeability
B
It causes relaxation of smooth muscle
C
It causes vasospasm
D
It induces pain when injected into the skin
Question 40
Cretinism refers to
A
iodine induced hyperthyroidism
B
granulomatous thyroiditis
C
hypothyroidism developing in infancy or early childhood
D
Stumaovarii
Question 41
Collapsing Glomerulopathy is
A
associated with parietal epithelial cell proliferation
B
a common manifestation of HIV nephropathy
C
associated with drug hypersensitivity
D
caused by thickening of glomerular basement membrane
Question 42
All of the following may be associated with nodular glomerular sclerosis except:
A
Diabetes
B
Light chain deposition disease
C
Cigarette smoking
D
Drug hypersensitivity
Question 43
Which of the following cytokine is NOT secreted by TH2 cells? 
A
IL-4
B
IFN-Υ
C
IL-5
D
IL-13
Question 44
Celiac disease is an immune mediated enteropathy associated with ingestionof
A
gluten
B
milk protein
C
endotoxin
D
kitin
Question 45
Metastatic calcification can occur in all of the following conditions EXCEPT
A
sarcoidosis
B
wide spread bone metastasis in breast cancer
C
hyperthyroidism
D
multiple myeloma
Question 46
MysosisFungoides is
A
a form of systemic fungal infection
B
cutaneous T-cell lymphoma
C
fungal infection of skin
D
associated with HIV
Question 47
All the following statements regarding clinical application of Next-Generation Sequencing is correct except:
A
Targeted sequencing is becoming popular in the clinical laboratories over whole genome analyses by Sanger sequencing
B
Whole Exome Sequencing (WES) is not helpful for broad survey for protein coding mutations
C
WES is a cheaper than Whole Genome Sequencing (WGS)
D
WGS is the only NGS application that can detect novel structural rearrangements.
Question 48
The transcription factor hypoxia-inducible factor 1 (HIF1)
A
inhibits new blood vessel formation
B
enhances anaerobic glycolysis
C
antagonize cell survival pathways
D
increases peroxinitrite formation
Question 49
Alport Syndrome
A
is an immunecomplex mediated glomerulonephritis
B
presents as rapidly progressive renal failure
C
causes diffuse thickening of glomerular basement membrane (GBM)
D
is associated with defective assembly of collagen IV in GBM
Question 50
Antineutrophil cytoplasmic autoantibodie (ANCA) is associated with
A
Crescentic glomerulonephritis
B
Diffuse glomerulosclerosis
C
Post streptococoal glomerulonephritis
D
IgA nephropathy
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